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Group picture 2022
Group picture 2022

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Welcome to the web site of the Proulx research group. We are a research group at NC State University interested in topics at the interface of Chemistry and Biology. In particular, we focus on the design, synthesis, folding, & function of peptide mimics. Please browse our web site or contact Prof. Caroline Proulx for more information.


11/29/2022 You can watch our video on the ACS Project SEED program here, with high school student Sheba Gage working on a collaborative project between the Proulx lab (Chemistry) and the Simpson and Barycki labs (Biochemistry). Emily Allego (graduate student), Sheba Gage, Skylar Harrelson (undergraduate student and Beckman Scholar), and Ellen Warner (graduate student) were all involved in this fun project.


11/11/2022  Hailey and Carolynn win poster awards...again! This time at the Boulder Peptide Symposium - congratulations!


11/09/2022 Congratulations to Ellen on passing her preliminary exam today - well done!


10/29/2022 We are excited to welcome three new graduate students to the group: Molly Carter, Karlee McKinney, and Kristy Witte!


08/12/2022 Congratulations to Carolynn on winning another poster award this summer, this time at the 11th peptoid summit!


07/22/2022 We are excited to announce that our NIH R35 Maximizing Investigators’ Research Award (MIRA) on 'New Strategies for Peptide Mimicry' was just funded! Special thanks to the NIH for the support, and to Carolynn and Max for all their hard work.

06/20/2022 The group welcomes Sheba Gage, an ACS Project SEED high school student that will be working with us this summer.


06/16/2022 Carolynn and Hailey both win poster awards at the American Peptide Symposium - way to go! 


06/15/2022 Caroline gives her Early Career Lectureship at the 27th American Peptide Symposium in Whistler, BC. You can see a summary of all the Proulx lab award from APS 2022 in the NCSU Department of Chemistry news here.


06/01/2022 The Proulx lab welcomes Katie Cartrette (NSF-REU student) and Skylar Harrelson (Beckman Scholar) - we are excited to work with you this summer!


05/18/2022 Congratulations to Hailey for the publication of her work on the "On-Resin Ca-Functionalization of N-Arylglycinyl Peptides with Boronic Acids" in Organic & Biomolecular Chemistry!


04/25/2022 Congratulations to Carolynn and Max for each receiving travel awards to attend and present at the upcoming American Peptide Symposium in Whistler, Canada!


04/07/2022 Congratulations to Hailey for placing 3rd in the Mathematical and Physical Sciences category at this year’s 15th Annual NC State Graduate Student Research Symposium!


03/16/2022 Congratulations to Max for winning a poster award at the annual Department of Chemistry poster session!


02/23/2022 Max's paper on the "Late-stage N-alkylation of azapeptides" is published in Organic Letters - Congratulations!


01/11/2022 Congratulations to Max for receiving the Burroughs Wellcome fellowship this Spring - well deserved!

12/14/2021 We received the CMI-CLP Research Initiatives at the Interface of Chemistry & Life Sciences award, which will initiate a collaboration with Prof. Melanie Simpson (PI) and Prof. Joe Barycki (co-PI).


11/11/2021 Congratulations to Max for passing his preliminary examination this morning!


05/21/2021  Congratulations to Carolynn, Brandon, Adam and Elon on the publication of their work "Submonomer Synthesis of Peptoids Containing trans-inducing N-imino- and N-alkylamino-glycines" in Chemical Science! A great team effort with support form the NSF-funded Integrated Computational and Experimental) (ICE) REU at North Carolina State University.


05/20/2021  Our book chapter on "Solid phase submonomer azapeptide synthesis" is now published in Methods in Enzymology. Check it out for some tips and a detailed protocol from Max on the solid phase submonomer azapeptide synthesis method. 


05/17/2021  Caroline receives the 2021 Early Career Lectureship from the American Peptide Society.


05/14/2021  Congratulations to Briley for receiving the Titanium award during last night's graduation ceremony! The Titanium  Award is given to a student that exhibits the strong and resilient properties of this metal in the classroom - very well-deserved!

05/14/2021  Congratulations to both Briley and Adam on their graduation yesterday! It was a pleasure to have them in the group and we wish them the best of luck with all their future endeavors.

05/05/2021  Meghan receives an undergraduate research award from the Office of Undergraduate Research - congratulations!


05/01/2021  We are excited to announce that Caroline's NSF CAREER proposal entitled "CAREER: Synthesis of Functional Biomolecules From Tunable N-Aryl Peptide Precursors" was funded! Thank you to NSF for the support and to all group members for their continued hard work. Special thanks to Dr. Quibria Guthrie and Hailey Young.


04/14/2021  Congratulations to Dr. Quibria Guthrie for passing her final PhD defense! Quibria was one of the first graduate student  to join the lab and accomplished many great things during her five years in the group. She will continue to work with peptides in her new role as a Research Scientist at CEM in Charlotte, NC. 


03/11/2021  We have another Ph.D candidate in the group! Congratulations to Carolynn for passing her preliminary exam!


02/22/2021  Join us this week (February 25th, 8EST) for our third online peptoid seminar symposium, with talks from Prof. Jumpei Morimoto, Prof. Galia Maayan, and student presentatons! Registration is free.


02/02/2021  Congratulations to Quibria for winning a poster prize at the NOBCChE 2020 Virtual conference!


12/10/2020  Join us next week (December 15th, 11EST) for our second online peptoid seminar symposium, with talks from Prof. Annelise Barron, Prof. Donghui Zhang, and student presentatons! Registration is free.


11/04/2020  Ellen Warner is the newest member of the the Proulx lab. Welcome to the group!


10/29/2020  Congratulations to Hailey for passing her preliminary doctoral exam today!


10/22/2020  We look forward to the first online session of the Peptoid seminar series on October 27th! Contact Caroline for more details on registration and/or abstract submission!


10/16/2020  Caroline gives a seminar over zoom to Research Triangle High School students to talk about peptide synthesis and medicinal chemistry - we hope to see you in person in the future! 


07/23/2020  Caroline contributes to a review article published in Biomedicines entitled "Synthesis and Biomedical Potential of Azapeptide Modulators of the Cluster of Differentiation 36 Receptor (CD36)", featuring some of her work as a graduate student in the Lubell lab at the University of Montreal in collaboration with the Chemtob and Ong labs.

06/23/2020  Evan successfully defends his MSc thesis. Best of luck with your next adventure!

05/31/2020  Check out Caroline's perspective on an article published in Science by the Pentelute lab, describing the use of automated flow chemistry for total chemical protein synthesis


05/05/2020  Caroline receives the LeRoy and Elva Martin Award for Teaching Excellence.


04/28/2020  Congratulations to Quibria for being awarded the Osteryoung Award for Research.


04/23/2020  Preston is selected as the winner of the Senior Award for Outstanding Scholarship in the Department of   Chemistry. Congratulations on all your accomplishments, Preston! He is heading to Vanderbilt University for graduate studies.


04/23/2020  Adam and Briley both receive undergraduate research awards from the Office of Undergraduate Research.


04/01/2020  Preston receives an honorable mention from the NSF GRFP competition this year - congratulations!


12/03/2019  Congratulations to Hailey and Quibria on their recently accepted publication in J. Org. Chem., featured in a special    issue on "Modern Peptide and Protein Chemistry".


10/21/2019  Preston represents the group at SERMACS this year, held in Savannah, GA.

10/18/2019  Maxwell Bowles officially joins the Proulx lab as a first year graduate student - welcome!


09/26/2019  Caroline presents the group's work at the Boulder Peptide Symposium!


08/29/2019  Our latest paper on ketoxime peptide ligation is published in Chemical Science. Congratulations to Quibria and Hailey! 


08/06-08/09  Caroline participates in the first Organic Syntheses Inc. Sponsored Workshop on Organic Synthesis for Young Investigators

08/01/2019  Preston, Brandon, and Kea, present at the 18th NC State University Annual Summer Undergraduate Research and  Creativity Symposium. Congratulations for a very productive summer!


06/22-06/28  The group travels to the American Peptide Symposium in Monterey, CA. Caroline gave a talk, while Quibria, Evan, Carolynn, and Hailey all presented posters. 

06/17/2019  The group welcomes ACS project SEED student Sophia Cornish.


05/28/2019  The group welcomes Brandon Lowe, who joins us from Saint Vincent College as an REU student.


04/21/2019  Congratulations to Michael, Evan, and Preston for their publication in Molecules! Their work is part of a special issue on Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery: A Themed Issue Honoring Professor Victor J. Hruby on the Occasion of His 80th Birthday.


04/29/2019  Congratulations to Evan Willis for receiving the Miles F. Anderson Award for Teaching!


04/09/2019  Caroline gives an invited talk at Seton Hall University - thanks to Dr. David Sabatino for the great day and the  invitation! 


03/31-04/04  Caroline and Quibria present at the ACS conference in Orlando, FL. 


03/23/2019  Congratulations to Quibria Guthrie for being awarded yet another travel award to attend the 26th American Peptide Symposium in Monterey, CA, on June 22-27, 2019. The group is looking forward to attending the APS this summer!

12/06/2018  Congratulations to Quibria Guthrie for being awarded an ACS Women Chemists Committee Travel Award, sponsored

by Eli Lilly & Company, to attend the 258th ACS National Meeting in Orlando, Fl! 


10/23/2018  The group welcomes first-year graduate students Carolynn Davern and Hailey Young! 

09/12/2018  Congratulations to Quibria Guthrie for passing her preliminary doctoral exam!


08/16/2018  Congratulations to Quibria Guthrie for being awarded a Burroughs Wellcome Fellowship for the Spring 2019 semester. Well done!

08/10/2018  Congratulations to Michael McMechen for passing his M.Sc. defense!

08/03/2018  Check out our SYNFORM article, highlighting our recent paper in Organic Letters. 


05/30/2018  Welcome to Jazmine Lumpan, who is joining our group for the summer from St. Edward’s University, Austin, Texas, as part of the Chemistry REU program.


04/25/2018  Our first paper  "Oxime Ligation via in situ Oxidation of N-Phenylglycinyl Peptides" is published in Organic Letters. Congratulations to Quibria! 


03/12/2018  Congratulations to Tyler, who received the Comins award at the annual Department of Chemistry poster session.

02/11/2018  Caroline presents a poster of the group's work at the Chemistry and Biology of Peptides GRC in Ventura, CA.


01/08/2018  Welcome back to Evan Willis, who has decided to come back to the Proulx lab as a graduate student!

08/14/2017  Welcome to Preston Gourville, an undergraduate student at NC State who has just joined our lab.


06/12/2017  Take a look at the Accounts of Chemical Research  article on "Azapeptide Synthesis Methods for Expanding Side-Chain Diversity for Biomedical Applications", featuring some of my graduate work with Prof. William D. Lubell. It is part of a special issue on the Chemical Biology of Peptides.


05/29/2017  Welcome to Carolynn Davern! Carolynn is an REU student from NC Wesleyan College. Her summer internship will include both an experimental component in our lab, as well as a computational component supervised by Dr. Elena Jakubikova and Dr. Elon Ison.


05/13/2017  Congratulations to Evan Willis, who graduated yesterday - well done! Evan will be spending the summer working at   the mass spectrometry facility (MSF) and continuing to work in the Proulx lab part time. 


10/31/2016  Check out Caroline's latest (and last!) publication from Berkeley lab, featured as the ACS Editors' Choice in Langmuir.

10/27/2016  Welcome to first-year graduate students Quibria Guthrie, Michael McMechen, and W. Tyler Price, and to undergraduate students Evan Willis and Tanner Roseborough.

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